Portrait of Suzanne Nyiranshuti, the Director of Nursing at Gisenyi Hospital, at the recently built Ebola Treatment Center in Rwanda. Nichole Sobecki/VII for the Global Fund

The Global Fund partnership has saved 
50 million lives since 2002

A strong return on investment


Every $1 paid by US taxpayers is matched by $2 from international donors


$31 in economic returns and health gains for every dollar invested


26% increase in life expectancy, from 52 years to 66 years, in 15 sub-Saharan African countries since 2002


20 additional years of life, on average, for an adult on low-cost TB treatment

Advances U.S. diplomatic and security interests and keeps Americans safe

When we invest in health systems around the world, we can contain pandemics at their source. A third of the Global Fund’s investments go toward building sustainable health systems that not only fight AIDS, TB and malaria, but also prepare for the emergence of new devastating diseases. The Global Fund invests in:

Diagnostic testing

Diagnostic testing

Training and supporting community health workers

Training and supporting community health workers

Disease surveillance

Disease surveillance

The Global Fund has disbursed $15 billion in challenging operating environments since 2002, helping to save lives and stabilize fragile conflict zones. U.S. investments in health can promote stability, mitigate extremism and avoid costly longer-term military interventions.

Countries that received support from the Global Fund were “associated with improved control of corruption, government accountability, political freedoms, regulatory quality, and rule of law.”

Olena, an HIV-positive woman in Ukraine, shows her daily HIV treatment. The Global Fund/ Evgeny Maloletka.

AIDS, TB, and malaria are preventable and treatable diseases that still kill more than 2.65 million people a year.

Broad, bipartisan, private sector, and faith-based support

“[50] million lives saved thanks to the Global Fund partnership and bipartisan Congressional leadership. What could be more impressive than that?”

– Former Speaker Nancy Pelosi (D-CA)

“The Global Fund has been one of the most successful programs in the history of government… The numbers speak for themselves.” 

– Senator Lindsey Graham (R-SC)

Last year, more than 20 global companies and 200 faith leaders urged Congress to fully fund the Global Fund.

But global crises threaten our progress.

War and food insecurity

Global conflict, in Ukraine and elsewhere, has disrupted health services and led to sharply higher food and energy prices.


COVID-19 devastated health systems around the world, disrupting hard-won gains in the fight against AIDS, TB, and malaria. TB is now poised to overtake COVID-19 as the world’s deadliest infectious disease, reclaiming the position it held before the pandemic.

Climate change

More frequent extreme weather events are causing destruction to health facilities and fueling upsurges in infectious diseases. Rising temperatures also move mosquitos to higher ground, causing malaria outbreaks in new areas.

Gender inequality

Due to persistent gender inequalities and barriers to education, adolescent girls and young women in sub-Saharan Africa are three times more likely to acquire HIV than adolescent boys and young men.

accountability and country ownership


Co-financing requirement

The Global Fund requires countries that receive grants to increase domestic financing for health.


Regular monitoring and data collection

The Global Fund evaluates and monitors activities before, during and after a grant has been implemented to ensure the proper use of grant funds and verify results and data.


Inspector general

Through its audits and investigations, the Global Fund Inspector General promotes best practices, reduces risk and identifies instances of fraud relating to Global Fund programs. This ultimately supports the Global Fund’s record of recovering resources in the limited number of cases in which the Inspector General has found funding to be misspent or misused.

U.S. Leadership is Critical to Ending the AIDS, TB, and Malaria Pandemics and Strengthening Global Health Security

Last year, the U.S. hosted a global fundraising event for the Global Fund and pledged $6 billion for three years, which encouraged the majority of G7 leaders to also increase their investments in the Global Fund by about 30%.

Speakers from the Presidential session of the Global Fund partnership’s Seventh Replenishment Conference celebrate the announcement of US$14.25 billion so far for the next three years of work to fight HIV, TB and malaria. The Global Fund/Tim Knox

Vera Kajawa passes out HIV medication to a mother and child at a clinic in Malawi.

Globally, women and girls face higher risks of HIV infection:

  • Educational barriers and stigma are driving health inequities
  • AIDS-related illnesses remain the number 1 killer of women of reproductive age, globally.
  • The Global Fund has provided over 7 million HIV-positive mothers with lifesaving medicine that also prevents transmission of HIV to their babies.
  • Educational barriers and stigma are driving health inequities
  • AIDS-related illnesses remain the number 1 killer of women of reproductive age, globally.